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Structurefunction analysis of Friedreich's ataxia mutants reveals determinants for frataxin binding and activation of the FeS assembly complex

In addition, we also recommend the use of bioinformatics tools and computational methods in aptamer screening and aptamertarget complex identification to overcome the disadvantages of SELEX techniques, which are tedious, time-consuming (usually taking several weeks to complete), and not cost-efficient [82]

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However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein