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Concurrently, antioxidant defense mechanisms, notably NRF2 and HO-1, are upregulated following testosterone exposure, likely as compensatory responses to increased reactive oxygen species (ROS) (Jahan et al., 2021)

If you have an MTHFR polymorphism, enzymatic reactions can slow down by 40-70%

Another BBB-crossing molecule with HGF-like activity, BB3, was employed in pre-clinical models of stroke, showing good functional improvements (Chaparro et al., 2015)