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In cell cultures and mouse models of HD as well as in patient samples, the levels of CSE are drastically diminished, due to the sequestration of SP1 by mHtt (Paul et al ., 2014)

FIGURE 1 Sodium-dependent vitamin C transporter 2 (SVCT2)-knockout mice die shortly after birth, with undetectable brain levels of vitamin C and diffuse hemorrhages in the cerebral cortex (Sotiriou et al., 2002

These symptoms sometimes indicate incorrect injection technique, an allergic reaction to the medication, or a localized infection that requires clinical evaluation