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Dynamics of newly-forming/formed OLs The differentiation of OPCs to generate new OLs and produce new myelin are essential processes for successful remyelination in human demyelinating diseases such as MS and in animal models of demyelination, although some recent studies have also argued for the contribution of pre-existing surviving mature Ols (Bacmeister et al., 2020

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Accordingly, the growth factor IGF-1 is produced as prohormone which contains a C-terminal domain, i.e

J Biol Chem (2002) 277(30):2672932

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