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In osteoarthritis, by deacetylating key proteins, SIRT1 activates the antioxidant response element (ARE), thereby upregulating the expression of antioxidant genes such as Nrf2, HO-1, and GPX4

Overall, Kanglexin protects neural tissue post-SCI by suppressing pyroptosis and shifting microglial phenotype via the PKA/NF-B signaling axis (Yan et al., 2025)