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These calculations use 15-30mcg/kg as the reference range

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Vascellari M, Melchiotti E, Bozza MA, Mutinelli F (2003): Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal fibrosarcomas

Thus, these data suggest that glycosylation of proIGF-1Ea is required for efficient IGF-1 production and secretion

however, this represents early-phase evidence only, and the mechanistic effects observed in trials including increased energy expenditure and lipolysis via glucagon receptor agonism have not yet been fully characterised in long-term human studies