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Several sub-cellular compartments generating ROS have been identified, including cytosol, peroxisomes, plasma, and endoplasmic reticulum (ER) membranes [26, 27]

Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury

If the mechanism is fairly focused but the dosing schedule is poorly chosen, the observed effects may reflect protocol strain, cumulative exposure patterns, or handling inconsistencies rather than the peptides intended pharmacology