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Results: A total of 229,419,579 participants (any: 65.1%, heavy: 5.3%) were included in the study

Estrogen has also been found to reverse chemotherapy resistance of ovarian cancer by targeting the Nrf2/GPX4 signaling axis to induce ferroptosis in drug-resistant human epithelial ovarian cancer cells (74)

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Oxidative stress has been implicated in pathogenesis of depression and several other brain disorders such as Parkinson's disease, Alzheimer's disease, bipolar disorder, major depression and schizophrenia (Sian et al., 1994