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Beyond the recruitment of proteasome subunits into the aggregates, ATXN3 misfolding can also impact protein degradation due to its direct role in the ubiquitin proteasome system (UPS) [57, 67, 68]

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes

Safety and efficacy of galantamine (Reminyl) in severe Alzheimer's disease (the SERAD study): a randomised, placebo-controlled, double-blind trial

Each vial is handled to meet laboratory-grade standards for purity and contamination control

PubMed: 17904615 Safety and Tolerability of AOD 9604 in Obese Subjects: Analysis of Adverse Events Across Multiple Trials review Liu X, Manzella D, Ng FM, et al