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Ann Thorac Surg 104(4):1103-1107, 2017

They may coexist within the same organism, the same tissue, or even the same cell

Biochim Biophys Acta 1830, 31653172 (2013)

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10.1136/bmj-2022-071609 112

Mechanistically, BHB enhances BDNF expression in the hippocampus of mice through epigenetic modulation, including inhibition of class I histone deacetylases, and through activation of CREB (cyclic adenosine monophosphate (cAMP) response element-binding protein)-dependent transcriptional pathways [59]