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73 A earlier meta-analysis of data from 17 randomized placebo-controlled trials with a total of 284 participants found melatonin supplementation improved sleep parameters, but the effects were small: in a subset of 15 trials in individuals who were either healthy or had insomnia but were otherwise healthy, the time needed to fall asleep decreased by 3.9 minutes, sleep efficiency improved by 3.1%, and total sleep time increased 13.7 minutes

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The systemic administration of caffeine failed to significantly affect pVTA salsolinol concentrations during pVTA perfusion with exogenous salsolinol (Fig