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Previous studies have demonstrated that the PI3K/Akt pathway plays important role in ICH injury

Specifically, the increased loss of RBCs leads to the increased formation of bilirubin, which further triggers eryptosis by enhancing both Ca 2+ influx, SMase activation, and ceramide production, thus creating a vicious cycle

doi:10.1080/07315724.1999.10718845

Crit Rev Food Sci Nutr 63(24):69006922 Zhao L, Mehmood A, Soliman MM, Iftikhar A, Iftikhar M, Aboelenin SM, Wang C (2021) Protective effects of ellagic acid against alcoholic liver disease in mice