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Research has shown that restoring MECP2 expression solely in GABAergic neurons of male mice can significantly improve multiple disease features in a Rett syndrome mouse model, including ataxia, apraxia, and social abnormalities (78)

Developing novel inducers with better pharmacokinetic properties or repurposing FDA-approved anticancer drugs with cell death-inducing activity may partially solve these limitations

WADA bans substances that lack regulatory approval for human use even if they are not specifically performance-enhancing

Chronic myeloid leukemia

All authors contributed to the work and have approved the content of the submitted manuscript

KD increases the expression and activity of UCPs in the hippocampus and enhances the efficiency of the mitochondrial electron transport chain by increasing UCP expression and reducing mitochondrial membrane potential [53], which leads to mitochondrial uncoupling and reduced production of mtROS [54-58]