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Overall, this study uncovers molecular hallmarks of mammalian mortality shared across organs, cell types, species and models of disease and rejuvenation, exposing fundamental mechanisms of aging and longevity

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This suggests that secreted listerial virulence factors whose synthesis is induced under intracellular conditions may modulate the metabolic host responses observed in this in vivo study and also in the above described 13 C-isotopolog studies with L

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To confirm the expression of SOD1 variants, NSC-34 cells, a motor neuron-like hybrid cell line, were transfected with SOD1 WT or SOD1 G93A constructs