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Reciprocal control of translation and transcription in autism spectrum disorder

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The decreased EpCAM caused the downregulation of CLDN1, CLDN7, OCLD and pIgR at the post-transcriptional level, and then the intestinal paracellular permeability increased and the dysbiosis of gut microbiota occurred, the paracellular flux of LPS from the intestinal lumen to blood also increased