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Earlier amylin analogs like pramlintide were short-acting and needed dosing with every meal, which made them a hassle and limited their reach

[DOI] [PMC free article] [PubMed] [Google Scholar] [65]

Additionally, some individuals may experience gastrointestinal disturbances such as stomach cramps, nausea, or diarrhea

In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks