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Expanding the availability of medications such as 5-SAS derivatives as a lower-cost alternative to biologics could improve access, but many patients remain unable to afford them due to limited supply and lack of awareness

In vitro models of the blood-cerebrospinal fluid barrier and their use in neurotoxicological research

[PubMed] [Google Scholar] 69.Gregory JF

Ying et al., 2024)

doi: 10.1186/s12967-025-06925-1

Varoglutamstat ( 17 , formerly PQ912), the first small molecule glutaminyl cyclase inhibitor to enter phase II clinical trials, targets an enzyme that catalyzes the conversion of glutamate to pyroglutamate at the N-terminus of A