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Apart from human studies, mice with heterozygous and homozygous mutation in Mthfr C677T still accompany with global DNA hypomethylation, decreased SAM and increased SAH levels 41

This vital nutrient is fundamental to DNA synthesis , the production of red blood cells, and the maintenance of the nervous system

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Chronic magnesium deficiency leads to widespread cardiovascular, neurological, and muscular problems (185)

The analysis also suggests that this interaction worsens neuropathy, but confounding by unknown factors could be responsible for this observation