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These variations are predominantly determined by external environmental factors rather than host genetic background (28), limiting both metabolite measurement reproducibility and clinical application reliability of biomarkers

The main issue with AMPs appears to be a risk to critical copper-based systems, as they impact on many key functions such as aerobic respiration, iron homeostasis, neurotransmitter synthesis and receptor modulation and vascular function that are key to AD

SFN and other isothiocyanates (ITCs) target HDAC turnover and activity, increasing the acetylation of histone substrates and leading to TSG activation (Gao and Tollefsbol 2015)

Proc Soc Exp Biol Med 216(2):192200 Guencheva TN, Henriques JAP (2003) Metabolismo de Xenobiticos: Citocromo P450