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That receptor spread is the reason people sometimes describe retatrutide as a "triple agonist" or, informally, a next-generation GLP-class compound

Alven, S., Peter, S., Mbese, Z., & Aderibigbe, B

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The study noted strongly stimulated dermal keratinocyte proliferation, indicating active tissue regeneration rather than merely surface effects

Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial