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MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors

Transl Psychiatry 2022;12, 375

Although the precise mechanisms remain to be fully elucidated, the role of D-lactate in mitochondrial regulation and redox balance suggests that it plays a significant role in metabolic dysfunction under specific pathological states

Recent studies have highlighted the role of Wnt/-catenin signaling in maintaining endothelial TJ integrity, as well as the regulatory influence of shear stress on endothelial cell function and tight junction assembly [30]