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The initial step for the de nov o synthesis of GSH occurs through the activity of glutamate-cysteine ligase, a heterodimer of a catalytic subunit and a modifier subunit that catalyses the first and rate-limiting step to form the dipeptide -glutamylcysteine from cysteine and glutamate (Reference Desideri, Ciccarone and Ciriolo27)

That last area is interesting in that it also applies to GI damage done by NSAID overuse a very important field of research

The association between TMAO, CMPF, and clinical outcomes in advanced chronic kidney disease: results from the European QUALity (EQUAL) Study

The calcium-binding capacity of osteocalcin requires vitamin K-dependent -carboxylation of three glutamic acid residues

A clinical diagnosis of drug-induced hepatic injury is easier to establish when the hepatotoxicity of the drug has been previously described and the associated clinical and pathologic features have been characterized (see discussion of specific drugs)