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Pro-brain natriuretic peptide (NPPB), a negative regulator of blood pressure that increases in response to heart damage, and troponin T (TNNT2), a heart muscle protein involved in contraction, had the strongest weights in the heart aging model (Fig

In particular, the function of the upregulated PH3 (Solyc10g084380.1.1) in PhAN4 HRC is rather to be associated with anthocyanin biosynthesis boosting than with acidification of pH, as tomato lacks PH1 and PH5 (i.e., the genes encoding the vacuolar P-ATPases which cooperate with PH3 and PH4 in determining flower color by hyperacidification of petal cell vacuoles in Petunia )

However, culture-independent barcoding approaches (e.g., PCR-DGGE) revealed the presence of Acidobacteria in AMZ [21], which can comprise up to 84.4% of the total bacterial abundance in AMZ [28]

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