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To prevent the spontaneous Fab arm exchange that IgG4 Abs undergo in vivo , rozanolixizumab harbors a S241P amino acid substitution in its hinge region that stabilizes the connection between the two HCs [124, 257]

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BPC-157 modulates the VEGFR2 pathway to promote angiogenesis, activates the FAK-paxillin system to enhance cell migration toward injury sites, and influences nitric oxide production for improved blood flow

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As an organ that is responsible for immune tolerance, the spleen is considered as immunosuppressed