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However, when dopaminergic neurons (the cells responsible for this conversion) are stressed in PD, their ability to perform this conversion becomes impaired

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in addition to its crucial role in maintaining genomic stability and regulating inflammation, SIRT6 also directly deacetylates NAMPT, enhancing its activity and promoting NAD + synthesis via the salvage pathway

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This can lead to an increase in blood flow to the brain, which can cause a temporary increase in intracranial pressure and result in a headache