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And the zeta-potential measured by the Nano Sizer and Zeta-potential analyzer of LNPs were determined to be 6.000.07 mV, while BUD-LNPs had a zeta-potential of 3.330.13 mV (Figure 2d), which enhanced their interaction with the negatively charged mucus network and facilitated their penetration and retention in the lungs

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While lipid-based nanoparticles (LNPs) have garnered significant clinical traction, evidenced by their successful deployment in mRNA vaccines and offering promise for challenging therapeutics like PROTACs (Table 2) [209, 210], the path to clinical translation for nanocarrier-based PROTAC delivery is fraught with hurdles

Compounds like CY-09, tranilast, and rabinosin reduce intracellular lipid droplet accumulation and ameliorate hepatic steatosis [155]

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