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Stem cell replenishment of the trabecular meshwork system in experimental glaucoma models has also been shown to act on underlying disease pathologies, with studies demonstrating improvements in IOP levels, aqueous humor outflow, trabecular meshwork cellularity, and RGC neuroprotection (Zhu et al., 2016

For instance, L-DON prevents the induction of PPAT and PAICS by glutamine and the reduction of pyruvate kinase activity [87] (Fig

Moreover, via its antioxidant properties, L-carnitine demonstrated neuroprotective effects

10 , e1004210 (2014)

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Missing doses or taking the supplement inconsistently can minimize its effectiveness