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Several potential confounding factors should be considered when interpreting the clinical findings

Annu Rev Pharmacol Toxicol 32(1):109134 Fiorucci S, Distrutti E, Cirino G et al (2006) The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver

Conclusions The outlined overview describes how SARS-CoV-2 can unbalance a high activity of the renin-angiotensin system in the lung via ACE2 downregulation, followed by free radical mediated inflammation, and unveils the protective role of GSH

Secondary antioxidant enzymes (glutathione reductase, glucose-6-phosphate dehydrogenase, glutathione-s-transferase, and ubiquinone) detoxify ROS and supply the NADPH and glutathione for primary antioxidant enzymes for proper functioning

Assessment of glutathione/glutathione disulphide ratio and S -glutathionylated proteins in human blood, solid tissues, and cultured cells