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352 Despite the promising results, challenges remain in standardizing treatment protocols and translating preclinical findings into clinical applications

Agomelatine agomelatine is an antidepressant agent with selective agonist action at melatonin receptors and selective antagonist action at serotonin 5HT-2C receptors does not affect uptake of serotonin, noradrenaline or dopamine abrupt withdrawal of agomelatine has not been associated with discontinuation symptoms - means that no dose tapering is necessary when stopping treatment no significant problems have been reported when agomelatine is taken with most other antidepressants so patients can be switched to and from this with negligible risk when switching from a MAOI to agomelatine, agomelatine can be started whilst gradually withdrawing the first antidepressant

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Diagnostics (Basel) 2021, 11

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It would be a boon to have available molecules with growth factor activity which are orally active, display profound growth factor activity, and yet are inexpensive to synthesize, for the treatment of dementia and PD