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By using in vivo imaging to identify deleterious microglial activation combined with targeted anti-inflammatory therapy to inhibit the common neurotoxic mechanisms of microglial activation, it might be possible to slow or halt the progression of neurodegenerative disease

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Zimmermann, Robert

This large size can impede diffusion within the dense tumor extracellular matrix, frequently restricting accumulation to perivascular regions and preventing penetration into hypoxic, acidic tumor cores, a limitation that contributes to heterogeneous therapeutic responses [221]

Cell Death Dis 14(3):176

Mahmoudi et al., Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues