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Not every study has demonstrated that oral B12 supplementation reduces the risk of deficiency in metformin users, which the researchers indicated may be explained because the dose of 0.6 g typically found in multivitamin supplements is inadequate for those on metformin treatment in terms of prophylaxis, 56 whereas other studies have found that multivitamin use was associated with reduced risk of deficiency

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For data not conforming to a normal distribution, comparisons between two groups were conducted using the MannWhitney U test, and comparisons among multiple groups were performed using the KruskalWallis ( H ) test

Available biomarkers of oxidative stress have been summarized in Table 3

Secondary Research Secondary research for this study involved the collection, review, and analysis of publicly available and paid data sources to build the initial fact base, understand historical market behaviour, identify data gaps, and refine the hypotheses for primary research

BMC Cancer 11: 180180 [DOI] [PMC free article] [PubMed] [Google Scholar] Tong C.Y., Hui A.B., Yin X.L., Pang J.C., Zhu X.L., Poon W.S., et al