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There is still a gap in existing research in the field, necessitating well-designed, robust, multicenter clinical trials with sensitive endpoints and standardized protocols to facilitate the diagnosis of DPN via a simple and effective algorithm and to track the progression of disease and treatment response

As the finale of this four-part series, this work underscores the need for multidisciplinary collaboration to integrate phytotherapeutics into evidence-based care, with the goal of improving developmental outcomes in pediatric neuroimmune disorders

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Increased intestinal permeability, chronic inflammation, oxidative stress, -synuclein aggregation, and neurotransmitter imbalances are some key factors that govern gastrointestinal pathology and PD progression