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This included circumvention of the complex downhill syndrome, as well as a sudden decrease of blood supply, decreased NO levels in the inferior caval vein tissue, an immediate heavy loss of endothelial cells from the vascular wall, a lower eNOS production ability (Rangan and Bulkley, 1993

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Although the condition is self-limited in most, resolution typically takes long, sometimes up to a year and a half

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The first 3 to 7 days are the most affected, with sleep onset latency increasing by 20 to 40 minutes

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