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Low dose buprenorphine (mu-opiate partial agonist and kappa receptor antagonist) was effective in an open-label, but not a double-blind clinical trial in treatment resistant LLD [209]

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In human MASLD patients, serum 2-OG levels in grade II and III hepatic steatosis patients are significantly higher than those in healthy subjects, suggesting that circulating 2-OG acts as a potential predictive biomarker for hepatic steatosis

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