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Description

ROS are known to stabilize HIFs in the hypoxic milieu in the brain [33]

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In MM medium, only the gdh3 / gdh3 mutant showed a significantly lower concentration of NADH, NADP + , and NADPH than the wild-type strain

The integration of omics data (e.g., transcriptomic, proteomic and metabolomic) into the risk assessment of chemical mixtures has great potential to reveal combined effects at a mechanistic level, providing insights into modes of action or adverse outcome pathways

In investigating the neurological and cognitive functions of aged mice in a study focused on the auditory cortex, the effect of alleviating ferroptosis in the brain was achieved by treatment with DFO, suggesting that DFO may be used to treat auditory and cognitive impairment resulting from age-associated problems (169)