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This leads to inefficient neurotransmission and contributes to excitatory/inhibitory (E/I) imbalance, often manifested as elevated extracellular Glu levels and reduced GABAergic tone

Parlesak A 1 , Bode C, Bode JC

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In the first step, glutamate reacts with cysteine to form -glutamylcysteine under the catalysis of the rate-limiting enzyme, -glutamylcysteine ligase (GCL)

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Molec Med (Cambridge, Mass) 29(1):73 Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ et al (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response