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[8] With advancing age, there is a decline in proteasome activity in cardiac tissue, which represents a significant mechanism contributing to the increased susceptibility of older organisms to cardiovascular diseases

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These users describe skin quality remaining noticeably superior to pre-treatment baseline even year post-discontinuation, with specific improvements including reduced fine lines maintaining 50-70% of treatment peak reduction, improved skin firmness and elasticity sustaining 40-60% of maximum improvement, better overall texture and appearance persisting at 50-80% of treatment levels, and completely resolved specific issues like scarring or hyperpigmentation staying improved

doi: 10.1007/s00438-012-0723-7 24