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Overall about 27 such cases have been reported, mostly in Japan with additional reports from Italy (39)

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S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

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In this context, ferroptosis exerts a context-dependent double-edged sword effect [127]: while targeted induction of ferroptosis in hyperproliferative PASMCs could theoretically reverse remodeling, uncontrolled ferroptosis leads to deleterious vascular injury [128, 129]

As the pH increases, the protein will be degraded, and the exposed hydrophobic amino acid residues point to the oil phase, while the hydrophilic groups point to the water phase, thereby enhancing the interaction with the oil phase (33)