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FIGURE 1 2.2 Search strategy A systematic search of scientific literature was conducted in the Web of Science (Core Collection), Scopus, and PubMed databases, including studies published up to November 2025 without country restrictions

Oil-balancing regulates sebum production, helpful for oily or acne-prone skin

Pour the crumbly dough onto a lightly flour surface

Lysates were clarified by centrifugation, and the resulting supernatant was incubated with 1 mL of Ni-NTA Agarose (Qiagen, 30210) for 1 h at 4 C

Gene therapy directly addresses the genetic cause of HCU, offering the possibility of durable metabolic correction

Phase III (transport and elimination) involves specialized transport proteins to pump the phase II conjugated toxins out of the cells