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Summary Keywords Zingiber species, Alpinia species, gingerols, zerumbone, immunomodulatory, signaling pathways Citation Yuandani, Jantan I, Haque MA, Rohani AS, Nugraha SE, Salim E, Septama AW, Juwita NA, Khairunnisa NA, Nasution HR, Utami DS and Ibrahim S (2023) Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review