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Lipinskis rule allows the violation of just a clause for a compound to be compliant to the rule ( TABLE 5 ADMET properties and drug-likeness of the most biologically potent derivatives

6, 2025, doi: 10.1130/abs/2025AM-7526

Research has shown that NEDD4 expression in the kidney and liver is regulated by 20-hydroxyeicosatetraenoic acid through the neddylation modification pathway [55] and that Nedd4-2 activation regulates the ubiquitination modification of renal NBCe1 [56]