Mitochondria: A promising convergent target for the treatment of amyotrophic lateral sclerosis
Counterfeit products and inconsistent quality control also pose reputational risks for legitimate manufacturers and distributors
PMID: 40493414 Nat Cancer The MEK-RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers
We hypothesized that high 15LO1, PEBP1, and GPX4 activity drives abnormal asthmatic redox biology, evidenced by lower bronchoalveolar lavage (BAL) fluid and intraepithelial cell GSH:oxidized GSH (GSSG) ratios, to enhance type 2 (T2) inflammatory responses
Interestingly, Gsta4, the main scavenger of the lipid peroxidation product 4-hydroxynonenal (4-HNE), has been predicted to be a target of Nrf2 51,52 , which we corroborated through the observation that both DMF and Clem-F induced the expression of Gsta4 (Fig
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