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Int J Food Sci Tech 55:303312

10.3389/fphar.2022.919905 135

doi: 10.1002/advs.202003937 145 ZhangF.QinY.XieL.ZhengC.HuangX.ZhangM

Dopaminergic neurons in the substantia nigra , the brain region most affected by Parkinson's disease, express receptors for an inflammatory cytokine called tumor necrosis factor-alpha (TNF-) , which suggests that excess TNF- released by nearby activated microglia may damage nigral dopaminergic cells