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This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)

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Antioxidants & Redox Signaling Vol

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[DOI] [PubMed] [Google Scholar] 495.Bravo JA, et al

In pediatric populations, congenital hypothyroidism and untreated iodine deficiency remain major causes of intellectual disability worldwide (81)