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doi: 10.1016/j.neubiorev.2014.05.011 3 ThummelKELinYS

Research designs that measure both local tissue concentrations and systemic pharmacokinetics help address this question

Studies are not entirely consistent, but they mostly report an increase in Akkermansiaceae and Methanobacteriaceae, and a decrease in SCFA-producing Bacteroidetes and Clostridia clusters (Atarashi et al., 2011

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[33] In chronic inflammatory bowel diseases, including Crohns disease, systematic reviews (including Cochrane reviews) have concluded that current randomized evidence is insufficient to support glutamine supplementation for inducing remission or modifying disease progression, and further well-powered clinical trials are required