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We supposed that Nrf2-mediated biosynthesis of GSH is impaired by the stimulation of CS, whereas GHK-Cu modulates Nrf2, attenuates pulmonary oxidative stress and thereby restores GSH depleted by CS

glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine TB-500: Molecular formula: C212H350N56O78S Molecular weight: 4963.5 Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

T.KersemansV.MichotteY.et al (2005)