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Additionally, cytochrome P450 reductase facilitates ferroptosis through the lipid peroxidation process, which begins with the peroxidation of PUFAs via electron transfer, a mechanism closely associated with the lipid peroxidation cascade ( Notably, molecules that regulate lipid peroxidation are critical in ferroptosis, as dysfunction of these regulators profoundly influences cellular fate

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Labont B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YHE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ (2017) Sex-specific transcriptional signatures in human depression