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Notably, the inhibitory effects of melittin on glycolysis are further enhanced when melittin is combined with an HSF1 inhibitor, providing a promising strategy to overcome cisplatin resistance in lung cancer [262]

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By combining rational peptide design, strategic amino-acid substitutions and albumin-binding acylation, with systematic, hypothesis-driven experimentation, investigators achieved a pharmacokinetic profile (approximately 160 h half-life) that made OW dosing clinically feasible without compromising receptor potency or safety

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These capabilities contribute to the amelioration of neurodegeneration, enhancement of positive behavioral outcomes, and upregulation of neuroprotective signaling pathways (Zheng et al., 2005)