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Therefore, sex differences were not expected to confound the age effect substantially

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Laboratory Handling & Safety Considerations Storage Protocol: Store lyophilized powder at 20C to 80C in dry conditions protected from light Reconstitute using appropriate sterile technique Store reconstituted solutions at 4C for short-term use Avoid repeated freeze-thaw cycles to maintain peptide integrity Create aliquots for single-use to preserve stability Research Observations from Literature: Published studies in animal research models report general tolerability with no major systemic toxicity observations in preclinical investigations

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*Correspondence: Wanqing Liu, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, Room 224B, West Lafayette, IN 47907, USA e-mail: [email protected] This article was submitted to Pharmacogenetics and Pharmacogenomics, a section of the journal Frontiers in Genetics