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a , We constructed a mutant strain that could not synthesize glutathione by knocking out, in the wild-type strain, the GSH1 gene which is essential for glutathione biosynthesis (see Mutant yeasts in the Methods section)

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doi:10.1002/ana.410360305 Pocernich CB, Butterfield DA

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Montagner P.S.S., Medeiros W., da Silva L.C.R., Borges C.N., Brasil-Neto J., de Deus Silva Barbosa V., Caixeta F.V., Malcher-Lopes R

Taken together, these observations constitute highly consistent evidence supporting the notion that free radical-associated effects of A42 require Met in position 35 of this neurotoxic peptide, and if Tyr10 is involved, we suggest that its role is likely relatively limited